Lilly starts Phase 3 plan for orforglipron in OA + obesity [5] [05 Sep 2025] Context: Interventional, randomized, parallel, single-blind design
masks hypoglycemia symptoms in diabetics Respiratory: Rare bronchospasm (less likely due to 1 selectivity) Others: Cold extremities, sleep disturbances Contraindications Severe bradycardia Heart block (2nd/3rd degree) Decompensated heart failure Severe asthma or COPD (use caution) Drug Interactions Other antihypertensives additive hypotension Antiarrhythmics additive bradycardia / AV block NSAIDs may reduce antihypertensive effect Class: Cardioselective 1-blocker Effect: HR, contractility, BP Major adverse effects: Bradycardia, hypotension, fatigue Uses: Hypertension, angina, post-MI, arrhythmias Mnemonic for Beta-Blocker Effects (HR & BP): BB lowers BP & beats (HR) To view or add a comment, sign in Beta Blockers Definition Beta blockers are drugs that block -adrenergic receptors, reducing the effects of adrenaline (epinephrine) and noradrenaline (norepinephrine) on the heart, lungs, and vasculature
For patients with underlying diabetes, the goal of steroid administration isnt to avoid giving dextrose entirely, but rather merely to reduce the dextrose requirement to a manageable level
Many published protocols use serial dilutions across two to three orders of magnitude to capture dose-response behavior
Future research might develop comprehensive education programs that provide patients with the tools and knowledge they need to prevent and manage GERD symptoms effectively
