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After crossing the BBB, the GLP-1RA binds to the GLP-1R and mimics the action of the GLP-1 hormone, stimulating the intracellular accumulation of cAMP, which via the action of PKA/RGNEF4 results in neuroprotective effects ( In the brain, GLP-1RAs perform anti-inflammatory, antioxidant, and anti-apoptotic functions (12)

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Baek KH, Ryeom S

Regular physical exercise is critical for managing comorbidities and lowering systemic inflammation, which has been associated to increased TMAO production [103109]