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As these drugs make weight loss easier, consumers may start to prefer healthier food options

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Darleen Sandoval Darleen Sandoval is in the Section of Nutrition, Department of Pediatrics and Division of Endocrinology, University of Colorado Anschutz Medical Campus, Aurora, Colorado 80045, USA

for instance, gain-of-function variants in KCNQ2 or KCNQ3 genes, which encode Kv7.2 and Kv7.3 subunits, have been associated with reduced pain sensitivity in individuals carrying a pro-excitatory Nav1.7 mutation, demonstrating how enhanced M-current can confer resilience to neuronal hyperexcitability (Estacion et al., 2023)

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