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Underlying mechanisms contributing to cardiovascular and renal protection are at least partially different between GLP-1RAs (mainly anti-atherogenic and vascular effects) and SGLT2is (mainly systemic and intrarenal hemodynamic changes)

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doi:10.1001/jama.2021.3224.

Initially, GLP-1 medication was only for treating diabetes because one of the main roles of GLP-1 is to boost the bodys insulin production

Each agent differs in molecular structure, half-life, and dosing frequency, but all share the core mechanism of GLP-1 receptor activation that influences multiple organ systems, including indirect effects on hepatic function