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Notably, excessive deposition of ECM within organs leads to the destruction or replacement of parenchymal tissue, irreversible scarring, and organ dysfunction or failure, such as heart failure, chronic renal failure, and chronic pancreatitis (King et al., 2011

Natural treatments with the highest scientific value for pigmentation include- Azelaic acid Ascorbic acid Beta arbutin Glycolic acid Salicylic acid Liquorice root extract, bearberry extract Fern extracts The best formulations depend on the type of pigment

Riboflavin is also cost-effective and has a minimal side effect profile (Condo 2009)

IVD degeneration impairs the function of the spinal unit (IVD, EPs, ligaments, facet joints and vertebral body), causing secondary osteoarthritic changes, bone sclerosis/spondylosis, and neurological signs and deficits due to spinal cord or nerve root compression [10]