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Similarly, it has been demonstrated that the phagolysosomal degradation of phagocytosed bacteria can provide carbon atoms and amino acids for the biosynthesis of itaconate and glutathione in macrophages
Additionally, activation of the ubiquitin-proteasome system and the lysosomal system leads to increased proteolysis and, accordingly, muscle destruction via up-regulation of atrogin-1 , MuRF-1 , cathepsin-L , PDK4 , p21 , Gadd45 and 4E-BP1 [60, 61]
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Emerging mitochondrial-mediated mechanisms involved in oligodendrocyte development