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Surprisingly, metformin prolonged the lifespan of mammals and decreased lung inflammation caused by COVID-19 in a mouse model of acute respiratory distress, possibly by blocking the activation of NLRP3 inflammasome through the inhibition of mitochondrial DNA synthesis (Xian et al., 2021)
This dual approach targets hunger and calorie intake more effectively than either drug alone
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The injection is typically self-administered by the patient at home after an initial in-clinic training session
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