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Some users say they've lost interest in things they once enjoyed: food, obviously, but also socializing, sex, alcohol and even favorite TV shows

There are potential limitations of their use in clinical studies

doi:10.1016/j.ejphar.2015.03.011 Rossini M, Di Munno O, Valentini G, Bianchi G, Biasi G, Cacace E, Malesci D, La Montagna G, Viapiana O, Adami S (2007) Double-blind, multicenter trial comparing acetyl l-carnitine with placebo in the treatment of fibromyalgia patients

When you do not know what is in a product, and it causes a skin reaction, you cannot even tell your doctor what you were exposed to