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GIP receptor activation Glucose-dependent insulinotropic polypeptide (GIP) is the second receptor target, similar to tirzepatide (Mounjaro, Zepbound): Effects: Enhances insulin release from the pancreas Works synergistically with GLP-1 for appetite control May influence fat storage and energy balance Improves glucose regulation Tirzepatide's success as a dual GLP-1/GIP agonist demonstrated that adding GIP to GLP-1 enhances weight loss beyond GLP-1 alone

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Specifically, we sought to determine the impact of estrous cycle phase (proestrus, estrus, metestrus and diestrus) on the response to a single dose of semaglutide (0.01 mg/kg) over a 24-h period of observation