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In recent years, with the increased understanding of p53's biological function, therapies targeting p53, including small-molecule drugs, cancer immunotherapies targeting p53, and gene therapies targeting p53, have gradually improved

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*Correspondence: Zhigang Ren [email protected] Yu [email protected] This article was submitted to Signaling, a section of the journal Frontiers in Cell and Developmental Biology These authors have contributed equally to this work Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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