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Gut microbiota and human NAFLD: disentangling microbial signatures from metabolic disorders

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Conversely, there is no evidence for accumulation of valproyl-CoA in brain tissue, suggesting that the effects of VPA in the CNS are independent of the formation of this metabolite [80]

In patients that completed 5 weeks of therapy in a controlled flexible dose pediatric adjunctive to stimulants study, 19% of patients treated with clonidine hydrochloride extend-release tablet+stimulant versus 7% treated with placebo+stimulant reported somnolence