This high potency has been independently confirmed and represents a well-characterized pharmacological property
In relation to diabetic cardiovascular diseases, in vivo studies in diabetic rats showed positive effects of ALA on the aortic arterial wall and angiogenic factors in the cardiovascular system, mainly on the myocardium [67,68]
4C, D, Supplementary Data 5-6)
Gynecological Endocrinology , 36(4), 362-367
Synthetic AT may be divided into two main categories: (i) those that have been primarily developed and synthetized as AT and (ii) compounds that primarily act via different mechanisms of action, while their AT properties were discovered later, which may contribute to their biological activity (as observed for some clinically used drugs, e.g., 4-aminosalicylic acid with inflammatory bowel disease (IBD))