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In these individuals the most common manifesting symptoms are leukoencephalopathy and peripheral neuropathy

We therefore suggest a mechanism that can be described according to the Cleland nomenclature as a combination of a random bi-uni mechanism and a ping-pong bi-bi (or uni-uni-uni-uni) mechanism in which the single product of the rate-limiting random mechanism becomes the first substrate of the ping-pong mechanism (Fig

Elle est prsente dans les muscles et les mitochondries cellulaires

doi: 10.1084/jem.20060925 13 FilippiMD

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