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Volume 1033, n1, pages 30-41

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The changes in renal function that are common after trauma and major surgery may lead to several-fold changes in the plasma concentrations of these substances (125), which renders the reliability of these markers questionable

Subcutaneous injections deliver consistently, can be administered on the patients schedule, and dont require a clinic visit each time

however, melatonin has a low impact on reducing MDA levels in rats treated with VPA, possibly due to the significant increase in these MDA levels in the hippocampus with the use of VPA [15]