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Reported or plausible effects discussed by users and in limited literature include injection-site irritation (if used by injection), headache, nausea, fatigue, lightheadedness, and changes in sleep

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As Dermatologist Katherine Armour, a Melbourne-based skin expert, says, "There is often a change in the appearance of many of their moles, such that it can be difficult to detect melanomas or sometimes, clinically, for us to exclude melanoma." Melanotan is classified as an unapproved product by Australias Therapeutic Goods Administration (TGA)

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In addition, frail or older patients with sarcopenia are not eligible for GLP-1RA plus SGLT2i combination therapy, as it could induce rapid and great reductions in body weight [82]