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Mutation of the acidic residues in the COPII binding region greatly reduced cell surface expression, with S protein accumulating in the ER, indicating that these residues direct efficient egress of the newly made S protein out of the ER and into the secretory pathway (Fig

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[DOI] [PMC free article] [PubMed] [Google Scholar] 49.Song J.Y., Huang J.Y., Hsu Y.C., Lo M.T., Lin C., Shen T.C., Liao M.T., Lu K.C