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Advantage : Neither (tie) Weight Loss Efficacy# CagriSema : REDEFINE 1 demonstrated 20.4% mean weight loss at 68 weeks

Furthermore, damage-associated molecular patterns (DAMPs) released by injured parenchyma cells act as additional pro-inflammatory stimuli, sustaining the inflammatory cascade, leading to rapid deterioration and potentially fatal outcomes 11,12

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Both medications work by mimicking the effects of GLP-1, stimulating insulin secretion, reducing glucagon secretion, and slowing gastric emptying, which helps regulate blood sugar levels and promote weight loss

Skin aging is characterized by reduced collagen density and dermal thickness, alongside a decline in the synthesis and replacement of important structural proteins [106, 107]