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Dietary supplementation with the n-3 PUFAs, EPA and DHA has been shown to significantly lower the risk of cardiovascular and all-cause mortality after MI in the GISSI-Prevenzione trial: Gruppo Italiano per lo Studio della Sopravvivenza nellInfarto Miocardico [69]

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However, the medication's gastrointestinal effects like diarrhea and constipation may indirectly contribute to conditions such as hemorrhoids or anal fissures that cause rectal bleeding

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Metoclopramide has traditionally been a first-line prokinetic therapy, but this agent should be administered at the lowest effective dose and for limited periods of time due to the real risk of adverse effects