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Pt II -02 to Pt II -04 complexes addressed the main disadvantages of free curcumin, including low bioavailability, photodegradability, and rapid oxidation

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For example, INT-777 and MN6, TGR5 selective agonists, stimulated GLP-1 secretion and improved insulin sensitivity in diet-induced obesity (DIO) mice [180, 181]

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