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Twenty caffeine-involved signaling pathways were related to NASH, such as chemokine signaling, cytokine-cytokine receptor interaction, phagosome, ECM-receptor interaction, PI3K-AKT signaling, MAPK signaling, Toll-like receptor signaling, NOD-like receptor signaling, and NF-B signaling

Asia-Pacific health agencies report earlier onset of diabetes, with China noting that 35% of new diagnoses now occur in adults under 45 years

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