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Lipid peroxidation, damage to the plasma membrane, fewer mitochondria, diminished mitochondrial cristae, and increased membrane density are the primary characteristics of ferroptosis [31, 32]

In animal work, raising NAD has been observed to shift healthspan markers in mice, with reported changes in mitochondrial function and sirtuin-mediated DNA repair (Mills et al., 2016)

Incorporating peptiderich skincare products or exploring peptide therapy under professional guidance may complement antioxidant strategies

reported that elevated ph-IOP disrupts retinal iron balance, causing Fe 2+ overload, particularly in the RGC layer (314)

For now, it occupies a middle position in our rankings, neither a standout nor a concern, but a viable option for price-sensitive patients willing to accept some operational rough edges