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Research on AD models has suggested that reactive astrocytes are more susceptible to neuronal reprogramming than their nonreactive counterparts, underscoring the role of astrocytic heterogeneity in influencing cell differentiation 25,149

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Vitamin B12 may reduce the effectiveness of some chemotherapy drugs, such as methotrexate or 5-fluorouracil, and may also be impacted by medications like metformin, proton pump inhibitors (PPIs), and certain antibiotics (e.g., chloramphenicol)

The addition reactions generally proceed through catalyzed Michael additions or free-radical additions

MTHFR enzymes are crucial components of glutathione synthesis