Some medical conditions like individuals with gastrointestinal disorders such as Crohns disease, and celiac disease, or those who have undergone gastric bypass surgery may also be at risk of developing vitamin B12 deficiency due to impaired absorption
Manganese has a role in Protein metabolism, disease resistance, bone, cartilage and connective tissue development, reproduction/fertility, ovulation, spermatogenesis, and embryo survival
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It first drew research interest for its ability to heal stomach ulcers and inflammatory bowel conditions, then expanded to tendon, ligament, muscle, and even bone healing across dozens of preclinical studies (Sikiric et al., PubMed)