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The data suggest oral semaglutide 25 mg could be a viable alternative for many patients, but it is not an uncomplicated one-to-one substitute

It is typically decided by a healthcare professional considering the patients tolerance to the prescribed dose

In all SURPASS programs, tirzepatide demonstrated a much greater HbA1c-lowering impact than placebo or active comparators, such as basal insulin and GLP1RAs [83, 86]

We extend the scope of our systems to a range of ring substitution patterns 11 and 12 and heterocycles 13 , providing a chemical toolbox for bioisosteric replacement of naphthalene, (iso)quinoline and quinazoline