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Furthermore, metformin can reverse resistance via the p53-PDK1-HKII pathway and by activating the AKT signaling pathway while inhibiting the IGF2R signaling pathway (46, 47)

Science 363 , 10881092 (2019)

Western blotting of 3xFLAG::NIS1b detected an approximately 36 kDa band ( Figure 8 ) that was larger than the size expected from the amino acid sequence alone (32 kDa), likely indicative of post-translational modifications

Adjustments to either medications dosage may be necessary to optimize outcomes