MRI may also show high density in bilateral basal ganglia, temporal lobe atrophy and extensive white matter hypodensity [74]
Additionally, iron can increase ALOX or EGLN proline hydroxylase (also known as PHD) activity, affecting cellular lipid peroxidation and oxygen homeostasis and thereby influencing cellular ferroptotic processes [40]
It also modulates nitric oxide, boosts growth factor signaling, and protects the gut-brain axis from damage due to stress, inflammation, or injury
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