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In fact: SSRIs often intensify emotional volatility when copper is high because serotonin metabolism is impaired

Unlike under oxidative stress where NRF-2 activation is mediated by oxidative inactivation of its sequester protein Keap-1, its activation under reductive stress was mediated by upregulation of an autophagy adaptor p62/SQSTM1, which also binds Keap-1 and thus enables nuclear translocation of NRF-2 and activation of its target genes (15)

However, a transient reduction in body weight was observed at week 5 in the 5% treatment group and may be attributed to taste aversion and reduced food intake