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Changes in glucose metabolism culminate in endothelial dysfunction and the activation of downstream inflammatory and pro-fibrotic pathways involving immune cell recruitment and TGF-1 production

Establishing a systematic incretin contactome atlas using super-resolution imaging and single-cell spatial omics will be vital to bridging these gaps and informing the design of next-generation therapies capable of precisely restoring intracellular structural and functional integrity ( A further layer of complexity is that MERCS remodeling is unlikely to follow a uniform, linear trajectory across tissues and disease stages

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10.1097/WCO.0000000000001093 27 CameronC.FiremanB.HuttonB.CliffordT.CoyleD.WellsG.et al