retatrutide test results TRANSCEND-T2D-1 topline are out : r/Zepbound Retatrutide Safety Testing Results &

doi: 10.1212/CPJ.0000000000001063

That means the additional weight loss driven by the glucagon receptor came predominantly from fat, not muscle

Retatrutide benefits and risks: independent news coverage

Semaglutide 2.4 mg (Wegovy): ~15% body weight loss at 68 weeks in clinical trials Tirzepatide 15 mg (Zepbound): ~21% body weight loss at 72 weeks in clinical trials Real-world data shows lower results: Cleveland Clinic research from 2025 found average weight loss of 7.7% with semaglutide and 12.4% with tirzepatide at one year in routine clinical practice

Lotosky, J., Jean, X., Altankhuyag, A., Khan, S., Bernotas, A., Sharafshah, A., Blum, K., Posner, A., & Thanos, P