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A pilot double-blind placebo-controlled trial of pioglitazone as adjunctive treatment to risperidone: Effects on aberrant behavior in children with autism

While this trial showed trends toward fat loss in the treatment groups, the primary endpoint of statistically significant weight reduction compared to placebo was not consistently achieved across all dose groups, and effect sizes were more modest than hoped

The clinical picture varies substantially between individuals the woman with severe insulin resistance and obesity faces a different therapeutic priority than the lean woman with a GnRH pulse disorder and normal metabolic indices and treatment should reflect that heterogeneity

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