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Following our previous work on natural fluorinase discovery and optimization ( our team used Ancestral Sequence Reconstruction (ASR) that I heard from Weiwei Zhai a few years ago, and successfully expanded the known diversity of these enzymes, producing seven new functional variants

Oral semaglutide (Rybelsus) is taken once daily as a tablet

This reflects enhanced fat oxidation providing consistent fuel even in the absence of recent food intake

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