semaglutide leptin restores astrocyte–vascular interactions and blood–brain barrier integrity in a model of diet-induced metabolic syndrome | Diabetology & Metabolic Syndrome Novel mechanisms involved in leptin

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There is sufficient evidence to suggest that, in an ideal world, trials should be undertaken with combinations of pioglitazone, SGLT2 inhibitors and long-acting GLP-1RAs to establish whether dual or triple therapy does, in fact, confer additional benefit over monotherapy in terms of reducing cardiovascular outcomes and saving lives