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These next-generation agents simultaneously target GLP-1 receptors along with additional metabolic pathways, including glucose-dependent insulinotropic polypeptide (GIP) and glucagon receptors, to enhance weight loss and metabolic outcomes

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The GLP-1 receptor agonist liraglutide reduces pathology-specific tau phosphorylation and improves motor function in a transgenic hTauP301L mouse model of tauopathy

Neither approach proves universally superior