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Higher levels of pro-inflammatory cytokines, including IL-1, IL-2, IL-4, IL-6, IL-7, IL-10, IL-13, IL-17, M-CSF, G-CSF, GM-CSF, and IP-10 have been reported in severe COVID-19 patients (Rodrigues et al., 2021

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The identification of this axis provides a novel mechanistic explanation for the fundamental paradigm that MI is not merely a localized ischemic event but a disease subject to systemic regulation