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In addition, the tumor inhibitory effects of sertraline can be further enhanced when combined with compounds causing mitochondrial dysfunction, e.g., rotenone, antimycin A, or the anti-malarial artemether in ser/gly-dependent breast cancer mouse models [34]

Nrf2 is a master conductor of the expression of hundreds of genes that promote the formation of many antioxidant/detoxifying enzymes and compounds (e.g., glutathione)

The implications of this finding are profound

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Brain Damage : Ethanol toxicity causes permanent damage to the brains cognitive function, leading to lasting impairments in memory, coordination, and motor skills