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Practical Application Consistent sleep schedule: Same bedtime/wake time, including weekends 7-9 hours nightly: Inadequate sleep duration increases DPP-4 Sleep quality: Deep, uninterrupted sleep matters more than just duration Light exposure: Bright light morning, dim light evening supports circadian rhythm Eat larger meals earlier in the day when DPP-4 activity is naturally lower Avoid late-night eating when DPP-4 activity peaks Morning protein intake may benefit from lower DPP-4 activity Strategy 6: Managing Inflammation and Metabolic Stress The Science: Chronic low-grade inflammation and metabolic stress significantly upregulate DPP-4 expression

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All recorded transmission spectra, T , were converted into absorption spectra, A : Absorption spectra were baseline corrected afterwards and normalization of the data was carried out applying the Euclidean norm: Every data point of each spectrum a k of wavenumber k is normalized to the square root of the sum of every spectrum data point

Interventions that target oxidative stress may help treat ED resulting from endothelial dysfunction