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Under hypoxia, CHCHD2 activates the transcription of itself and COX4I2 , which encodes cIV subunit-4 isoform 2 (COX IV-2) ( CHCHD2 show reduced cIV activity in addition to cI deficiency (Lee et al., 2018)

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We would like to note that peer grouping [Step 7 in the methodology] hospitals based on the number of measure groups for which they report at least three measures is intended to improve comparability of Overall Hospital Quality star ratings by accounting for differences in measure information

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The results demonstrated a significant reduction in this ratio upon HC and CCCP administration, indicating mitochondrial depolarization (Figures 7B,C)