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One letter each was issued to a firm in South Africa, Canada, and Australia, and only one letter was issued to a domestic firm

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doi: 10.1093/carcin/21.3.361

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These effects are largely underpinned by its capacity to modulate pivotal signaling cascades, including NF-B, Nrf2, and MAPK pathways ( Acteoside significantly lowered blood glucose, improved serum creatinine and BUN levels, and reduced 24-h total urinary protein in a rat model of diabetic nephropathy (unilateral nephrectomy combined with streptozotocin)