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Across 5 clinical trials with an exposure time of at least 52 weeks, 4 of 245 subjects (1.6%) were positive for antibodies against setmelanotide

It works primarily by increasing norepinephrine release in the hypothalamus, the part of the brain that controls hunger, which suppresses appetite, she explains

The investigators pre-select what is referred to as a primary outcome

"It is important to appreciate, however, that the increased risk relates to a disorder that is relatively uncommon," he added in a hospital news release

How to Self-Administer a SubQ Injections This overview is for educational purposes only, and should not replace or substitute guidance from your provider