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Niosomes decorated with dual ligands targeting brain endothelial transporters increase cargo penetration across the bloodbrain barrier

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These end-products bind cellular receptors of AGEs (RAGEs) that promote the production of reactive oxygen species (ROS), nuclear factor kappa-B (NF-B), and pro-inflammatory cytokines such as interleukin (IL)-1, IL-6, IL-18, tumor necrosis factor-alpha (TNF-) that induce the intracellular production of abundant ROS, and initiate oxidative stress/inflammation cascade

Since GLP-1 medications often reduce appetite and overall food intake, some people may find it more difficult to consistently consume enough protein, fiber, vitamins, minerals, and other important nutrients