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In short, they are reported to increase the growth of intestinal epithelial cells, enhance intestinal barrier function, influence immune cell development and populations in the gut-associated lymphoid tissue, exert anti-inflammatory and potentially T H 1 promoting and/or T H 2 inhibiting effects on various intestinal immune cells, and modify the abundance of gut microbiota that might play a role in allergic sensitization (Figure 1)

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C., Shaw, C

doi:10.1001/jama.2022.9009 Shen S, Bethina Liu, Chad Fanti, et al

Tier 1 is well-validated core therapies consisting of lifestyle interventions, metformin, insulin, and second-generation sulfonylureas