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A study in rats on the potential hepatotoxicity of geniposide revealed that high doses of geniposide (574 mg/kg or more) causes acute hepatotoxicity after 2448 h of oral administration, an effect that may be related to oxidative stress, whereas normal doses of geniposide (24.3 mg/kg or less) do not cause hepatotoxicity, even when repeatedly administered for 90 consecutive days (Qiu et al., 2024)

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With aging, Klotho levels decrease, while Wnt signaling increases accordingly, which in turn promotes fibrosis and vascular calcification ( In addition, peroxisome proliferator-activated receptor- (PPAR) agonists have been found to enhance Klotho expression

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