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6 Perspective: The intersecting burdens of HBV infection, alcohol use, and liver cancer While the oncogenic mechanisms of HBV, including viral DNA integration, chronic liver inflammation, and HBV protein-driven signaling, are well characterized, growing evidence highlights alcohol consumption as a potent and often underrecognized cofactor linked to disease progression

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(d) a very long-term follow-up period (till death as end-point), with assessment of both clinical features and serial determinations of the biological markers

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