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N Engl J Med (1987) 317:53741

A Research Study to See How Semaglutide Works Compared to Placebo in People With Type 2 Diabetes and Chronic Kidney Disease (FLOW)

The guide focuses on three keys that are crucial to optimal GLP-1 strategy: Coverage important considerations to inform your approach Cost utilization management strategies that can help rein in spend Care how personalized clinical and nutrition support can boost clinical efficacy and may even help some members avoid medication It also links to additional resources, including: Case study: Smart logic PA in action Our smart logic PA solution helps limit coverage for off-label use of GLP-1s approved to treat type 2 diabetes

Gastrointestinal Effects GLP-1 medications have significant effects on the digestive system: They slow stomach emptying, increasing feelings of fullness They reduce gastric acid production They may help with inflammatory bowel diseases They enhance gut barrier protection They have anti-inflammatory effects in the digestive tract While these effects help with weight loss and blood sugar control, they can also cause side effects like nausea, vomiting, and diarrhea