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It acts as a selective inhibitor of nicotinamide N-methyltransferase (NNMT), an enzyme expressed in multiple tissues including adipose tissue and the liver that plays a role in cellular energy metabolism and fat storage

B12 in the form of methylcobalamin, works as part of an enzyme (something that speeds reactions) called methionine synthase that enables these metabolic cycles to run properly

This process is analyzed in relation to VEGFR2 signaling, Akt/eNOS pathways, endothelial cell survival, and the regulation of repair mechanisms in connective tissues

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