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An earlier meta-analysis specifically on probiotics for functional constipation reported similar conclusions, with response varying by genus, species, and even strain.[6] HN019 is a useful case study in honest reading

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Mortality in HICs has declined significantly over the past two decades, with current estimates between 1520%, yet the economic burden remains substantial, with per-patient costs ranging from $20,000 to $50,000 (2, 3)