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Mitochondrial dysfunction in autism spectrum disorders: Cause or effect

In the SURMOUNT-1 trial at the highest dose, lean mass decreased by 5.67 kg or 10.9% from baseline, with only 25.7% of total weight lost coming from lean mass

Cell culture Baby hamster kidney (BHK) cells stably over-expressing human, cynomolgus, rat, mouse and pig GLP-1 receptor, human glucagon receptor, human GIP receptor, human GLP-2 receptor or co-expressing hGLP-1R and cAMP response element (CRE) coupled to firefly luciferase (CRE luciferase) were generated at Novo Nordisk A/S

However, subgroup analyses showed no significant differences in HbA1c-lowering ability between the two groups (test for subgroup difference 3 mg: P = 0.2

It's also worth saying that it's unlikely that semaglutide will remain this expensive in the long-term future