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An MTHFR result does not determine whether folic acid, folinic acid, methylfolate, methyl-B12 or other methylation support is appropriate

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Another group independently also concluded that disability progression and brain atrophy occur earlier than in the classical secondary progressive stage, with many relapsing patients exhibiting insidious progression without clinical or radiographic evidence of inflammatory disease activity, coining the term silent progression (Cree et al., 2019)