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MOTS-c is a mitochondrial-derived peptide (MDP) encoded within the mitochondrial genome that improves cellular energy metabolism, insulin sensitivity, and exercise capacity through AMPK activation and metabolic regulation

The oxidant stress that results from impaired homocysteine metabolism, which modifies the intracellular redox status, might play a central role in the molecular mechanisms underlying moderate hyperhomocysteinemia-mediated vascular disorders

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