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Controlling and combatting oxidative stress is an important goal for treating and preventing major chronic disease

202 Firstly, DNA methylation regulates different insulin signaling genes, such as insulin ( INS ), insulin receptor substrate 1 ( IRS1 ), Insulin-like growth factor-1/2 (IGF-1/2), Insulin-like growth factor-binding protein 1/2 (IGFBP-1/2), phosphatidylinositol 3-kinase regulatory subunit (PIK3R1), and Glucagon-like peptide-1 receptor (GLP-1R)